Acriflavine 10
Acriflavine
CAS: 8048-52-0
Molecular Formula: C27H25ClN6
Acriflavine 10 - Names and Identifiers
| Name | Acriflavine |
| Synonyms | Euflavin Acriflavine XANTHACRIDINE Acriflavine 10 Trypaflavine Neutral GUANOSINE ULTRA PURE GRADE Acriflavine 〔Trypaflavine〕 4-Acetamino phenol ( APAP ) 3,6-Diamino-10-methylacridinium chloride 2,8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE |
| CAS | 8048-52-0 |
| EINECS | 999-999-2 |
| InChI | InChI=1/C14H13N3.C13H11N3.ClH/c1-17-13-6-5-10(15)7-9(13)8-11-12(16)3-2-4-14(11)17;14-9-4-5-12-8(6-9)7-10-11(15)2-1-3-13(10)16-12;/h2-8,16H,15H2,1H3;1-7H,14-15H2;1H |
Acriflavine 10 - Physico-chemical Properties
| Molecular Formula | C27H25ClN6 |
| Molar Mass | 468.98 |
| Density | 1.0933 (rough estimate) |
| Melting Point | 179-181 °C |
| Boling Point | 612.69°C (rough estimate) |
| Solubility | Soluble in water (330 mg/ml), ethanol, and alcohol (1:40). Insoluble in ether, and chlo |
| Appearance | Powder |
| Color | Deep orange to brownish-red |
| Merck | 14,123 |
| Storage Condition | Room Temprature |
| Refractive Index | 1.6000 (estimate) |
| MDL | MFCD00064307 |
| In vitro study | Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells. |
| In vivo study | Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis. |
Acriflavine 10 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R50 - Very Toxic to aquatic organisms R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S29 - Do not empty into drains. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | AR9660000 |
| HS Code | 38249064 |
Acriflavine 10 - Reference
| Reference Show more | 1. [IF=6] Xiaoqing Tan et al.Deep Learning-Assisted Visualized Fluorometric Sensor Array for Biogenic Amines Detection.Chinese Journal Of Chemistry.2021 Nov 10 |
Acriflavine 10 - Introduction
Added to the base of the Lileria enrichment broth.
Last Update：2022-10-16 17:29:04
Acriflavine 10 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Acriflavine is a fluorescent dye used to label high molecular weight RNA. It is also a topical antiseptic. |
| Use | biochemical research |
Last Update：2024-04-09 02:00:12
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